The Effect of Diphenylhydantoin
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چکیده
This work was previously published in abstract form in Clin. Res. 17: 288, 1969. Dr. Larsen's present address is the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa. 15213. Received for publication 10 November 1969 and in revised form 4 February 1970. concentration. If free thyroxine is the only portion of the hormone available for cellular utilization, then free thyroxine clearance must be increased in these subjects. This increase in clearance could represent either a direct stimulation of peripheral thyroxine metabolism by diphenylhydantoin, or it could reflect the response of intrinsic regulatory systems to a diphenylhydantoin-mediated displacement of thyroxine from thyroxine-binding globulin. Whatever the mechanism for this effect, a decreased free thyroxine value in patients receiving diphenylhydantoin may not imply hypothyroidism.
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تاریخ انتشار 2013